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KMID : 0605619980050020227
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Journal of Korean Society of Biological Psychiatry
1998 Volume.5 No. 2 p.227 ~ p.234
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The Effects of Chronic Carbamazepine Administration on Protein Kinase A and Protein Kinase C Activities in Rat Brain
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1임두원/1Doo Won Rheem
2김인/2서광윤/2Leen Kim/2Kwang Yoon Suh
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Abstract
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Objective : Many evidences suggest that patients with bipolar disorder have functional
abnormalities in their postreceptor signal transduction pathways, and mood stabilizing
effect of lithium is exerted by modulating this dysfunctioning system. Carbamazepine, an
antiepileptic agent, is also known to be effective in the treatment and prevention of
bipolar disorder. But the precise mechanism of action of the drug is still poorly
understood. This study was performed to elucidate the possible therapeutic mechanism
of carbamazepine.
Method : The effects of chronic carbamazepine administration on protein kinase A and
protein kinase C activities in frontal cortex of rat brain after 2 weeks of drug
administration were measured and compared with those of control subjects.
Results : Mean(±SE) value of activity(phosphate transfer μmol/mg of protein, min)
or protein kinase A in control and test group was 0.249563±0.036 and 0.539853±0.078,
and that of protein kinase C was 0.654817±0.053 and 1.146205±0.052 respectively, being
increased in test group. And differences between the two groups were statistically
significant for both enzymes(protein kinase A ; p<0.01, protein kinase C ;p<0.001).
Conclusion : These results show that chronic carbamazepine administration increases
protein kinase A and C activities, and concerning the possible mode of therapeutic action
in bipolar disorder it is suggested that enhanced enzymes phosphorylate
receptor-G-protein-effector complexes to dampen hyperfunctioning neuronal activity and
thus stabilize the system.
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